The series follows the life of San Francisco-based Christopher Chance (Mark Valley), a unique private contractor, bodyguard and security expert hired to protect his clients. Rather than taking on the target's identity himself (as in the comic book version), he protects his clients by completely integrating himself into their lives, to become a \"human target\". Chance is accompanied by business partner Winston (Chi McBride) and hired gun Guerrero (Jackie Earle Haley). Former client Ilsa Pucci (Indira Varma) becomes Chance's benefactor, while experienced thief Ames (Janet Montgomery) joins the team to seek redemption. Chance puts himself on the line to find the truth behind the mission. Even his own business partner Winston does not know what drove him towards this life, although it is explained in the first-season finale episode (which also explains about the name Christopher Chance itself).
Human Target was renewed for a second season in May 2010. Matt Miller took over as showrunner from Jon E. Steinberg who remained part of the production team as an executive producer. Warner Bros. had contacted Miller to take a look at the first season and give his opinions on what changes he would make to the show.
Composer Bear McCreary scored the music for the first season, for which he received an Emmy Award nomination for Outstanding Main Title Theme Music. He wanted to create a modern classic-adventure score\", and a heroic but still fun and iconic theme for Chance. Chance's theme later became the opening theme for the first season. McCreary wrote around 30 minutes of full orchestral music for 11 weeks in a row, which was performed by an average of 60 musicians. The score for the final episode of the season, \"Christopher Chance\", was performed by a total of 94 musicians, making it the largest live orchestra ever assembled for a television series. McCreary was not asked back for the second season as they could no longer afford a weekly 40-person orchestra. Chuck composer Tim Jones took over the role.
The series premiered in Canada on CTV on January 15, 2010, and began airing on Fox two days later. The first three episodes aired in various time slots on Fox; it premiered on Sunday at 8:00 pm ET; the second episode aired Wednesday at 9:00 pm ET; and the third episode aired Tuesday at 9:00 pm ET before relocating to its regular time slot for the remainder of the season, Wednesday at 8:00 pm ET. The first seasons' finale aired April 11, 2010 in Canada and three days later in the U.S. The second season was due to premiere on September 24, 2010 but later delayed to October 1, airing in a new time slot, Fridays at 8:00 pm ET. Instead of airing the season premiere Fox aired a rerun of Human Target and moved the show back to Wednesdays, taking Lie to Me's time-slot, which had moved to Mondays due to the cancellation of Lone Star. The second season premiered November 17, 2010 on Fox and originally aired Wednesdays at 8:00 pm ET. In January 2011, back-to-back episodes aired on January 5 and 14. Due to network coverage of the Tucson memorial service, the two scheduled episodes did not air in the United States on Fox, but they aired in Canada on A. The episodes were rescheduled and aired on January 14, 2011 on Fox. The next scheduled episode to air on January 26 was to be delayed and aired January 31, airing Monday at 8:00 pm ET. The final two episodes of the season aired on February 2 and 9, airing in another new timeslot, Wednesdays at 9:00 pm. Fox canceled the series on May 10, 2011.
A two-disc soundtrack containing 43 tracks composed by Bear McCreary for the first season was released by WaterTower Music on October 8, 2010. A limited three-disc soundtrack with an additional 20 tracks was released on October 22 the same year by La-La Land Records.
The series premiere of Human Target received generally favorable reviews, scoring 69 out of 100 on Metacritic based on 26 critical reviews. On Rotten Tomatoes, the season has an approval rating of 62% with an average rating of 6.8 out of 10 based on 29 reviews. The website's critics consensus states, \"Human Target is frequently preposterous, but this slam-bang action series also offers a solid mix of comedy and thrills\". The New York Post stated, \"because he's a human target, he has no problem blowing out of exploding buildings (of which there are too many to count) with nary a scratch. Think Jack Bauer with excellent grooming\". Robert Bianco wrote of the show's premiere in USA Today that the \"confined-spaces fight on the train is a miniature marvel of its kind\". Not all reviews were positive. Cynthia Fuchs gave the show a 3 out of 10, calling it predictable and the characters uninteresting.
The second-season premiere received similar favorable reviews, scoring slightly higher than the first season with 71 out of 100 on Metacritic based on 13 reviews. On Rotten Tomatoes, the season has an approval rating of 88% with an average rating of 7.2 out of 10 based on 24 reviews. The website's critics consensus states: \"Action-packed sequences and the addition of two central female characters give Human Target's second season a necessary boost\". Brian Lowry from Variety criticized the changes made to the second season believing that the producers were forced to give the show an overhaul by the network to make it more appealing to women. He believes the changes almost ruined the show for those who loved the first season, but he said \"for all that, there are still some good moments in these early hours, and the stuntwork remains impressive\". He was also happy to see the scheduling changes keeping the show away from the Friday night death slot. Some reviewers wondered what happened to the original theme music, with Ian Cullen going as far as to say that \"the change of music in the opening title sequence just plain sucked\".
In the U.S. the series premiere attracted 10.12 million viewers, and dropped to 7.24 million viewers for the season finale. The first season averaged on 8.26 million viewers and became 48th in viewers. In Canada the premiere was watched by 1.26 million people, ranking 21st in that week.
The second season continued the drop in viewers and premiered to 6.59 million viewers. Viewership increased for the final three episodes of the second season, when the show aired in special time slots. Notably, episode 12 which aired after American Idol, received 9.3 million viewers, a season-high, and the best ratings the series has had since the beginning of the first season.
Human Target was a television action series that was based on a DC Comics character created by Len Wein and Carmine Infantino. Mark Valley starred as Christopher Chance, a unique security contractor whose unique way of protecting his clients was by completely integrating himself in their lives and thus himself becoming the target. The series aired for two seasons on FOX from 2010 to 2011 and co-starred Chi McBride and Jackie Earle Haley.
Baptiste: I don't get you, we were a good team and then you have to become a Dudley Do-Right. Nobody deserves to die. Everybody deserves to die, as far as someone is concerned. That's human nature, and you told me that.Chance: I was wrong. permalink
Human Target was a 2010 TV series starring Mark Valley as Christopher Chance, the Human Target. The series ran for two seasons, but was subject to inconsistent scheduling. It aired on Fox mostly, but the Canadian network CTV was ahead of them for much of the first season.
The events of the series happen in San Francisco and follow the life of Christopher Chance, a unique private contractor, bodyguard and security expert hired to protect his clients. Rather than taking on the target's identity himself (as in the comic book version), he protects his clients by completely integrating himself into their lives, to become the human target...
In the end, If I ever get the chance to review the second season, I will do so. For this show really stands as proof that you can do action shows with both high production values and excellent scripts.
Methods and results: AZD6482 is a potent, selective and ATP competitive PI3Kβ inhibitor (IC(50) 0.01 μm). A maximal anti-platelet effect was achieved at 1 μm in the in vitro and ex vivo tests both in dog and in man. In dog, in vivo AZD6482 produced a complete anti-thrombotic effect without an increased bleeding time or blood loss. AZD6482 was well tolerated in healthy volunteers during a 3-h infusion. The ex vivo anti-platelet effect and minimal bleeding time prolongation in the dog model translated well to data obtained in healthy volunteers. AZD6482 inhibited insulin-induced human adipocyte glucose uptake in vitro (IC(50) of 4.4 μm). In the euglycemic hyperinsulinemic clamp model, in rats, glucose infusion rate was not affected at 2.3 μm but reduced by about 60% at a plasma exposure of 27 μm. In man, the homeostasis model analysis (HOMA) index increased by about 10-20% at the highest plasma concentration of 5.3 μm.
Conclusions: This is the first human target validation for PI3Kβ inhibition as anti-platelet therapy showing a mild and generalized antiplatelet effect attenuating but not completely inhibiting multiple signaling pathways with an impressive separation towards primary hemostasis. AZD6482 at 'supratherapeutic' plasma concentrations may attenuate insulin signaling, most likely through PI3Kα inhibition.
\"Everyone's afraid to die, Mr. Chance ... unless for some reason they think they deserve it.\" That's a line from a very good scene in the second season premiere of Fox's \"Human Target\" (Wednesday, 9 p.m./8 Central), a show about an ex-assassin turned bodyguard. Adapted by Jonathan E. Steinberg (\"Jericho\") from a very different comics series by Len Wein and Carmine Infantino, it had a stellar debut season. Then it just fell apart. It's not beyond repair, but it seems to have settled into good-enough-for-government-work much sooner than I expected. It had better save itself fast; viewers are fickle. 59ce067264